In this issue of \u003ci\u003eDermatologic Clinics\u003c/i\u003e, guest editors Drs. Darrell S. Rigel, Joshua Burshtein, Milaan Shah, and Danny Zakria bring their considerable expertise to the topic of \u003cb\u003eMelanoma and Pigmented Lesion Update\u003c/b\u003e. Top experts in the field discuss trends in melanoma incidence and mortality; risk factors for primary cutaneous melanoma; lesional markers and precursors of melanoma; histopathology of melanoma; AI in melanoma: diagnosis and management; and more.\u003cul\u003e\u003cli\u003eContains \u003cb\u003e14 relevant, practice-oriented topics\u003c/b\u003e including the role of sunscreen in protection from melanoma; updated techniques for melanoma diagnosis; staging systems for cutaneous melanoma; surgical management of malignant melanoma; Mohs micrographic surgery for melanoma; and more\u003c/li\u003e\u003cli\u003eProvides in-depth \u003cb\u003eclinical reviews on melanoma and pigmented lesion update, \u003c/b\u003eoffering actionable insights for clinical practice\u003c/li\u003e\u003cli\u003ePresents the \u003cb\u003elatest information on this timely, focused topic\u003c/b\u003e under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews\u003c/li\u003e\u003c/ul\u003e